Specific Inhibition by Ethidium Bromide of Mitochondrial Dna Synthesis in Physarum Polycephalum
نویسندگان
چکیده
Eucaryotic cells contain two complete genetic systems, one based on nuclear DNA and the other on cytoplasmic DNA . The study of these systems has been greatly facilitated by the existence of specific inhibitors . One such inhibitor is the trypanocidal drug, ethidium bromide (Short, Peak, and Watkins, 1953) . Application of the drug to trypanosomes in vitro causes alterations in the structure of their kinetoplast (mitochondrial) DNA (Riou and Delain, 1969) . In HeLa cells, ethidium bromide (EtBr)l inhibits the synthesis
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عنوان ژورنال:
- The Journal of Cell Biology
دوره 49 شماره
صفحات -
تاریخ انتشار 1971